Oxidative Cross-Coupling

Palladium-catalyzed aerobic oxidative cross-couplings of indoles and benzene have been achieved by using 4,5-diazafluorene derivatives as ancillary ligands. Proper choice of the neutral and anionic ligands enables control over the reaction regioselectivity.

"Regiocontrolled aerobic oxidative coupling of indoles and benzene using Pd catalysts with 4,5-diazafluoreneligands"

 Campbell, A. N.; Meyer, E. B.; Stahl, S. S. Chem. Commun. 201147, 10257-10259.  PDFSupporting Info.